CELL BASED ASSAYS

Developers of vaccines, gene and cell therapies, monoclonal antibodies or other types of biologics need to accurately measure and predict the immunological responses mediated by, or developed against, their drug candidates. Immune cells are at the heart of these complex biological mechanisms and their functions and characteristics require highly specialized skills and technologies to be fully deciphered.  Well-designed cellular assays represent the key to any successful preclinical or clinical program and can make the difference between a cost efficient, direct path to IND and a convoluted, expensive development path wrought by ill-informed decisions, repeats and setbacks. High quality cellular data are key to identifying, screening and validating candidates through all stages of development from discovery to safety, immunogenicity and efficacy studies.

cell based assays, cellular assay

As a leading CRO in cell based assays, ABL offers:

  • Sample testing in support of both preclinical and clinical programs
  • Expert advice on the most relevant and applicable cellular methods
  • Custom assay development, method transfer and fit-for-purpose method validation
  • State-of-the-art instrumentation to accommodate the latest techniques

ABL’s expertise in cellular assessments includes:

  • T and B cell ELISpot
  • FluoroSpot
  • Immunophenotyping
  • T/B/NK Cell Enumeration
  • Intracellular Cytokine Staining (ICS)
  • Tetramer and Multimer Staining
  • Lymphoproliferation
  • Neutralizing Antibody (NAb) assays
  • Antibody Dependent Cell-mediated Cytoxicity (ADCC)
  • Complement Dependent Cell Cytoxicity (CDC)
  • Antibody-mediated Opsonization / phagocytosis
  • Other needs? Inquire here

cell based assays, cellular assays

ABL scientists support and strengthen our clients’ programs such as:

  • Target selection
  • Lead optimization
  • Preclinical development
  • Proof of Concept
  • Dose determination
  • Mechanism of action
  • Combination therapies
  • Immunogenicity
  • Efficacy

CASE STUDY

Comprehensive Phenotyping of Immune Cell Subtypes

ABL’s wide assortment of platform instrumentation empowers our experts to create and execute comprehensive solutions that meet your grandest cellular goals.

Cellular Technology Suite:

Interested in knowing more about cell-based assays?